报告题目：The unbearable stress of Being

 ---A mouse model of PTSD: the network and molecular bases

报告人：  　Xiang Li, Ph.D

 Department of Neuroscience

Columbia University 

时间：      　2014年12月30日（周二），下午：14:00-16:00

地点：      　西区生物楼531会议室

主办单位：中国科学技术大学生命科学学院

　　　　　合肥微尺度物质科学国家实验室

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报告简介：

An enduring question in the study of stress-related psychiatric illness is why some individuals are more vulnerable to the effects of stress than others. In the course of studying the prion-related RNA binding protein TIA-1, a novel mouse model of post-traumatic stress disorder (PTSD) was established. Compared to wild-type controls, TIA-1-deficient mice develop heightened anxiety and avoidance behavior after exposure to contextual fear conditioning, but are otherwise indistinguishable from wild-type littermates in the naive state. These behavioral phenotypes are associated with abnormal stress-dependent synaptic plasticity in the hippocampus. The prion-like properties of TIA-1 were further characterized in budding yeasts. Tia1/Pub1 acts co-operatively with the release factor Sup35/eRF3 to establish a two-protein self-propagating state. This two-protein prion driven by the Q/N-rich prion domains of Sup35 and Tia1/Pub1 can be visualized as distinctive line structures along tubulin cytoskeleton and unveil the role for prion domains in the assembly of multi-protein complexes.